Advanced systemic mastocytosis: the impact of KIT mutations in diagnosis, treatment, and progression
Mutation D816V Alters the Internal Structure and Dynamics of c-KIT Receptor Cytoplasmic Region: Implications for Dimerization and Activation Mechanisms | PLOS Computational Biology
![Advanced systemic mastocytosis: the impact of KIT mutations in diagnosis, treatment, and progression - Verstovsek - 2013 - European Journal of Haematology - Wiley Online Library Advanced systemic mastocytosis: the impact of KIT mutations in diagnosis, treatment, and progression - Verstovsek - 2013 - European Journal of Haematology - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/9f946845-fd37-4f9c-a0bc-eb91a2a24fa5/ejh12043-fig-0001-m.jpg)
Advanced systemic mastocytosis: the impact of KIT mutations in diagnosis, treatment, and progression - Verstovsek - 2013 - European Journal of Haematology - Wiley Online Library
![Nintedanib targets KIT D816V neoplastic cells derived from induced pluripotent stem cells of systemic mastocytosis - ScienceDirect Nintedanib targets KIT D816V neoplastic cells derived from induced pluripotent stem cells of systemic mastocytosis - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0006497121000021-fx1.jpg)
Nintedanib targets KIT D816V neoplastic cells derived from induced pluripotent stem cells of systemic mastocytosis - ScienceDirect
Hotspot Mutations in KIT Receptor Differentially Modulate Its Allosterically Coupled Conformational Dynamics: Impact on Activation and Drug Sensitivity | PLOS Computational Biology
![IJMS | Free Full-Text | Recent Advances in the Molecular Biology of Systemic Mastocytosis: Implications for Diagnosis, Prognosis, and Therapy IJMS | Free Full-Text | Recent Advances in the Molecular Biology of Systemic Mastocytosis: Implications for Diagnosis, Prognosis, and Therapy](https://www.mdpi.com/ijms/ijms-21-03987/article_deploy/html/images/ijms-21-03987-g001.png)
IJMS | Free Full-Text | Recent Advances in the Molecular Biology of Systemic Mastocytosis: Implications for Diagnosis, Prognosis, and Therapy
![Targeting KIT by frameshifting mRNA transcripts as a therapeutic strategy for aggressive mast cell neoplasms: Molecular Therapy Targeting KIT by frameshifting mRNA transcripts as a therapeutic strategy for aggressive mast cell neoplasms: Molecular Therapy](https://www.cell.com/cms/attachment/185ee84e-9422-444c-b3d4-b8f3b145ecc6/fx1_lrg.jpg)
Targeting KIT by frameshifting mRNA transcripts as a therapeutic strategy for aggressive mast cell neoplasms: Molecular Therapy
![Detection of the c-kit D816V mutation in systemic mastocytosis by allele-specific PCR | Journal of Clinical Pathology Detection of the c-kit D816V mutation in systemic mastocytosis by allele-specific PCR | Journal of Clinical Pathology](https://jcp.bmj.com/content/jclinpath/61/1/109/F2.large.jpg)
Detection of the c-kit D816V mutation in systemic mastocytosis by allele-specific PCR | Journal of Clinical Pathology
![KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis | Leukemia KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis | Leukemia](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fleu.2015.24/MediaObjects/41375_2015_Article_BFleu201524_Fig1_HTML.jpg)
KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis | Leukemia
![Bidirectional sequencing of KIT exon 17 demonstrated a D816V mutation... | Download Scientific Diagram Bidirectional sequencing of KIT exon 17 demonstrated a D816V mutation... | Download Scientific Diagram](https://www.researchgate.net/publication/270219022/figure/fig4/AS:295146722742273@1447379870379/Bidirectional-sequencing-of-KIT-exon-17-demonstrated-a-D816V-mutation-in-the-diagnostic.png)
Bidirectional sequencing of KIT exon 17 demonstrated a D816V mutation... | Download Scientific Diagram
![KIT and mastocytosis-associated mutations. The receptor for SCF is KIT... | Download Scientific Diagram KIT and mastocytosis-associated mutations. The receptor for SCF is KIT... | Download Scientific Diagram](https://www.researchgate.net/publication/41420036/figure/fig2/AS:276491293216777@1442932069493/KIT-and-mastocytosis-associated-mutations-The-receptor-for-SCF-is-KIT-CD117-a-145-kDa.png)
KIT and mastocytosis-associated mutations. The receptor for SCF is KIT... | Download Scientific Diagram
KIT D816V and the cytokine storm in mastocytosis: production and role of interleukin-6 | Haematologica
![Detection of the KITD816V mutation in myelodysplastic and/or myeloproliferative neoplasms and acute myeloid leukemia with myelodysplasia-related changes predicts concurrent systemic mastocytosis | Modern Pathology Detection of the KITD816V mutation in myelodysplastic and/or myeloproliferative neoplasms and acute myeloid leukemia with myelodysplasia-related changes predicts concurrent systemic mastocytosis | Modern Pathology](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41379-019-0447-x/MediaObjects/41379_2019_447_Fig1_HTML.png)
Detection of the KITD816V mutation in myelodysplastic and/or myeloproliferative neoplasms and acute myeloid leukemia with myelodysplasia-related changes predicts concurrent systemic mastocytosis | Modern Pathology
![Single-cell analysis reveals the KIT D816V mutation in haematopoietic stem and progenitor cells in systemic mastocytosis - eBioMedicine Single-cell analysis reveals the KIT D816V mutation in haematopoietic stem and progenitor cells in systemic mastocytosis - eBioMedicine](https://www.thelancet.com/cms/attachment/e90bea87-f358-4fcc-826e-10461d94f54e/gr4.jpg)
Single-cell analysis reveals the KIT D816V mutation in haematopoietic stem and progenitor cells in systemic mastocytosis - eBioMedicine
![Eurofins DiscoverX c-Kit (D816V) Protein, Active Quantity: 250 μg Eurofins DiscoverX c-Kit (D816V) Protein, Active | Fisher Scientific Eurofins DiscoverX c-Kit (D816V) Protein, Active Quantity: 250 μg Eurofins DiscoverX c-Kit (D816V) Protein, Active | Fisher Scientific](https://assets.fishersci.com/TFS-Assets/CCG/product-images/GEL%2014-611%20c-Kit%20(D816V).JPG-650.jpg)
Eurofins DiscoverX c-Kit (D816V) Protein, Active Quantity: 250 μg Eurofins DiscoverX c-Kit (D816V) Protein, Active | Fisher Scientific
![KIT D816 mutated/CBF-negative acute myeloid leukemia: a poor-risk subtype associated with systemic mastocytosis | Leukemia KIT D816 mutated/CBF-negative acute myeloid leukemia: a poor-risk subtype associated with systemic mastocytosis | Leukemia](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41375-018-0346-z/MediaObjects/41375_2018_346_Fig1_HTML.png)